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J Low Genit Tract Dis. 2008 Jul;12(3):199-203. doi: 10.1097/LGT.0b013e318160b9a5.

High-grade cervical disease in adolescents with HIV.

Author information

1
Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA. massadl@wudosis.wustl.edu

Abstract

OBJECTIVE:

To estimate the risk of high-grade squamous intraepithelial lesions (HSIL) in adolescents with HIV.

MATERIALS AND METHODS:

Review of cervical cytology and biopsy results from women aged 20 years and younger obtained within 3 years of enrollment in a prospective multicenter study.

RESULTS:

At enrollment, none of 132 adolescent participants (45 HIV seropositive and 87 seronegative) had HSIL or cervical intraepithelial neoplasia grade 2 or 3 (CIN 2,3). Eight (7%) of 123 women with follow-up developed high-grade disease after a median of 2.6 years of observation. The incidence of HSIL/CIN 2,3 was 2.7/100 person-years (4.8/100 person-years in HIV seropositive and 1.6/100 person-years in HIV seronegative women; relative risk = 3.1; 95% CI = 0.76-12.74; p =.13). No cancers were found in adolescents during the study.

CONCLUSIONS:

The low incidence of HSIL or CIN 2,3 in adolescents suggests that optimal management is careful observation rather than preventive treatment of low-grade abnormalities.

PMID:
18596461
PMCID:
PMC4507508
DOI:
10.1097/LGT.0b013e318160b9a5
[Indexed for MEDLINE]
Free PMC Article
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