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Semin Immunol. 2008 Jun;20(3):181-6. doi: 10.1016/j.smim.2008.04.002. Epub 2008 Jul 2.

The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche.

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  • 1AIDS and Cancer Virus Program, Science Applications International Corporation-Frederick, Inc., National Cancer Institute, Frederick, MD, USA.

Abstract

The hallmark of HIV/SIV infections is the progressive depletion of CD4+ T cells that ultimately renders the host incapable of defending against AIDS defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4+ T cell loss, we review here the growing evidence that fibrotic 'scarring' and consequent damage to the lymphatic tissue niche contributes to CD4+ T cell decline and limits CD4+ T cell re-population with retroviral therapy.

PMID:
18595731
PMCID:
PMC2650387
DOI:
10.1016/j.smim.2008.04.002
[PubMed - indexed for MEDLINE]
Free PMC Article

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