Format

Send to

Choose Destination
Eur J Clin Pharmacol. 2008 Oct;64(10):987-92. doi: 10.1007/s00228-008-0500-z. Epub 2008 Jul 2.

Chloroquine pharmacokinetics in pregnant and nonpregnant women with vivax malaria.

Author information

1
Mahidol-Oxford Tropical Medicine Research Unit, MORU, Mahidol University, Bangkok, Thailand.

Abstract

PURPOSE:

We compared the pharmacokinetics of chloroquine in pregnant and nonpregnant women treated for Plasmodium vivax malaria.

METHODS:

Twelve pregnant women and 15 nonpregnant women of child-bearing age with acute P. vivax malaria were treated with 25 mg chloroquine base/kg over 3 days on the northwestern border of Thailand. Blood concentrations of chloroquine and desethylchloroquine were measured using hydrophilic interaction liquid chromatography coupled with fluorescence detection. Twenty-five women completed the pharmacokinetic study.

RESULTS:

Although increasing gestational age was associated with reduced chloroquine AUC0-->infinity, there was no significant difference overall in the pharmacokinetics of chloroquine between pregnant and nonpregnant women. Fever was associated with lower chloroquine AUC0-->infinity values. Desethylchloroquine area under the curve (AUC) values were not significantly affected by pregnancy.

CONCLUSIONS:

Pregnancy did not significantly affect blood concentrations of chloroquine or its metabolite, desethylchloroquine, in women with P. vivax malaria.

PMID:
18594802
DOI:
10.1007/s00228-008-0500-z
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center