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Bioessays. 1991 Apr;13(4):157-61.

Titin, a huge, elastic sarcomeric protein with a probable role in morphogenesis.

Author information

1
Department of Biochemistry, University of Iowa, Iowa City 52242.

Abstract

Titin, the largest protein identified to date (over 1 micron long, almost 3 million daltons in mass) is the third most abundant component of the sarcomere. In the mature myofibril, titin molecules span from M line to Z line, forming a third filament system which provides sarcomeric alignment and elastic recoil. In the developing sarcomere, accumulating evidence from studies both in vivo and in vitro implicates titin as part of a morphogenetic scaffolding, upon which critical events in myofibrillogenesis are coordinated in a time- and space-dependent manner.

PMID:
1859393
DOI:
10.1002/bies.950130403
[Indexed for MEDLINE]

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