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J Org Chem. 2008 Aug 15;73(16):6207-12. doi: 10.1021/jo800624m. Epub 2008 Jul 2.

General and efficient copper-catalyzed amidation of saturated C-H bonds using N-halosuccinimides as the oxidants.

Author information

1
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, PR China.

Abstract

We have developed a general and efficient method for copper-catalyzed amidation of saturated C-H bonds under mild conditions, and the used substrates include benzylic reagents, the N, N-dimethylaniline derivatives, the free carboxamides, and sulfonamides. The protocol uses inexpensive and readily available CuBr/ N-halosuccinimide (NBS or NCS) as the catalyst/oxidant, so it provides practical applications for synthesis of various amides via C-H activation.

PMID:
18593184
DOI:
10.1021/jo800624m
[Indexed for MEDLINE]

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