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Nat Cell Biol. 2008 Jul;10(7):755-7. doi: 10.1038/ncb0708-755.

Cdh1: a master G0/G1 regulator.

Author information

1
Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, MSB 599, New York, NY 10016, USA.

Abstract

APC/C(Cdh1) controls the G0 and G1 phases of the cell cycle. Using a conditional knockout of the Cdh1 coding gene Fizzy-related (Fzr), a new study demonstrates that Cdh1 is essential for viability and that it functions as a tumour suppressor by preventing genomic instability.

PMID:
18591966
PMCID:
PMC2730193
DOI:
10.1038/ncb0708-755
[Indexed for MEDLINE]
Free PMC Article

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