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Kidney Int. 2008 Jul;74(2):141-3. doi: 10.1038/ki.2008.219.

Targeted ablation of the vitamin D 1alpha-hydroxylase gene: getting to the heart of the matter.

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1
Renal Unit and the Center for D-Receptor Activation Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA. thadhani.ravi@mgh.harvard.edu

Abstract

Targeted gene ablation technology has uncovered biological mechanisms that have led to important therapeutics in humans. In a study by Zhou et al., ablation of the 1alpha-hydroxylase gene led to hypertension, cardiac hypertrophy, and systolic dysfunction, and this cardiac phenotype was rescued with exogenous 1,25-dihydroxyvitamin D administration.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00497146 NCT00616902.

PMID:
18591942
DOI:
10.1038/ki.2008.219
[Indexed for MEDLINE]
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