Format

Send to

Choose Destination
Ann N Y Acad Sci. 2008;1129:358-70. doi: 10.1196/annals.1417.005.

Peripheral circadian oscillators: interesting mechanisms and powerful tools.

Author information

1
Institute for Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.

Abstract

The lives of plants, animals, and human beings are all regulated by circadian clocks. In mammals, 24-hour rhythms of physiology and behavior are directed by a master clock in the suprachiasmatic nucleus (SCN) of the brain hypothalamus, which in turn entrains "slave" oscillators of similar molecular composition in most cells of the body. These peripheral clocks are interesting not only because they control many aspects of circadian physiology, but also because they are model systems through which we understand how the SCN regulates complex behavior. To this end, peripheral oscillators have been exploited both biochemically to understand the proteins that make up biological clocks, and genetically to decipher the ways in which individual differences in human chronotype might arise.

PMID:
18591495
DOI:
10.1196/annals.1417.005
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley Icon for Zurich Open Access Repository and Archive
Loading ...
Support Center