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Cell Metab. 2008 Jul;8(1):7-9. doi: 10.1016/j.cmet.2008.06.010.

The double life of Irs.

Author information

1
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10027, USA.

Abstract

The liver plays a central role in lipid and glucose metabolism. Two studies in this issue (Kubota et al., 2008; Dong et al., 2008) on the insulin-signaling adaptors Irs1 and Irs2 prompt a critical reappraisal of the physiology of fasting and of the integrated control of hepatic insulin action.

PMID:
18590687
PMCID:
PMC2712626
DOI:
10.1016/j.cmet.2008.06.010
[Indexed for MEDLINE]
Free PMC Article

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