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J Stroke Cerebrovasc Dis. 2008 Jul-Aug;17(4):212-7. doi: 10.1016/j.jstrokecerebrovasdis.2008.02.005.

Cortical atrophy and white matter hyperintensities in HIV: the Hawaii Aging with HIV Cohort Study.

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1
Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI. aaronmnm@hawaii.edu

Abstract

BACKGROUND:

As many human immunodeficiency virus (HIV)-seropositive individuals are now living longer after infection because of highly active antiretroviral therapy, aging-related manifestations of cerebral small-vessel ischemic vascular disease, such as brain white matter hyperintensities (WMHs), are becoming increasingly important in this population.

GOALS:

This study was designed to determine the relationship between WMHs and cortical volumes in HIV-seropositive individuals.

MATERIALS AND METHODS:

Voxel-based morphometry was used to compare cortical volumes among 62 HIV-seropositive individuals participating in the Hawaii Aging with HIV Cohort Study, 30 with moderate WMHs and 32 with minimal or no WMHs.

RESULTS:

Presence of moderate WMHs was associated with decreased cortical volumes in the frontal lobes bilaterally.

CONCLUSION:

These findings suggest that age-related WMHs are associated with reduced frontal gray matter volumes in HIV-seropositive individuals, supporting the hypothesis that the frontal lobes may have greater susceptibility to the effects of small-vessel ischemic vascular disease.

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