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FEBS Lett. 2008 Jul 23;582(17):2601-8. doi: 10.1016/j.febslet.2008.06.038. Epub 2008 Jun 25.

The effect of MinC on FtsZ polymerization is pH dependent and can be counteracted by ZapA.

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Department of Molecular Microbiology, Institute of Molecular Cell Biology, VU University Amsterdam, De Boelelaan, The Netherlands.


The min system prevents polar cell division in bacteria. Here, the biochemical characterization of the interaction of MinC and FtsZ from a Gram-positive bacterium, Bacillus subtilis, is reported. B. subtilis MinC inhibits FtsZ polymerization in a pH-dependent manner by preventing the formation of lateral associations between filaments. The inhibitory effect of MinC on FtsZ polymerization is counteracted by the presence of ZapA, a protein that promotes FtsZ filament bundling.

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