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FEBS Lett. 2008 Jul 23;582(17):2601-8. doi: 10.1016/j.febslet.2008.06.038. Epub 2008 Jun 25.

The effect of MinC on FtsZ polymerization is pH dependent and can be counteracted by ZapA.

Author information

1
Department of Molecular Microbiology, Institute of Molecular Cell Biology, VU University Amsterdam, De Boelelaan, The Netherlands. dirk-jan.scheffers@falw.vu.nl

Abstract

The min system prevents polar cell division in bacteria. Here, the biochemical characterization of the interaction of MinC and FtsZ from a Gram-positive bacterium, Bacillus subtilis, is reported. B. subtilis MinC inhibits FtsZ polymerization in a pH-dependent manner by preventing the formation of lateral associations between filaments. The inhibitory effect of MinC on FtsZ polymerization is counteracted by the presence of ZapA, a protein that promotes FtsZ filament bundling.

PMID:
18588879
DOI:
10.1016/j.febslet.2008.06.038
[Indexed for MEDLINE]
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