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Org Lett. 2008 Aug 7;10(15):3291-4. doi: 10.1021/ol8011309. Epub 2008 Jun 28.

Dynamic combinatorial libraries constructed on polymer scaffolds.

Author information

1
School of Chemistry, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK. d.a.fulton@ncl.ac.uk

Abstract

Functionalized polymers were prepared by grafting acylhydrazides onto a polyvinylbenzaldehyde scaffold through reversible hydrazone linkages. The dynamic nature of these linkages allows the functionalized polymers to exchange and reshuffle their appendages, and the resultant mixture of polymers can be considered as a dynamic combinatorial library constructed upon a polymer scaffold. The dynamic nature of these functionalized polymers was demonstrated.

PMID:
18588307
DOI:
10.1021/ol8011309
[Indexed for MEDLINE]
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