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Urol Int. 2008;80(4):451-3. doi: 10.1159/000132708. Epub 2008 Jun 27.

Neoadjuvant therapy with sorafenib in advanced renal cell carcinoma with vena cava extension submitted to radical nephrectomy.

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1
Department of Urology, University of Rome, Rome, Italy.

Abstract

A 71-year-old man with advanced left renal cell carcinoma (lymph node involvement and vena cava thrombus) was submitted to 6 months of neoadjuvant treatment with sorafenib before open radical nephrectomy. After sorafenib treatment and before surgery a new CT scan confirmed the presence of a 9.0 cm in diameter solid mass in the left kidney but a reduction in thrombus extension, limited to the left renal vein. At histological examination after radical nephrectomy, over 90% of the renal mass was substituted by necrotic tissue.

PMID:
18587261
DOI:
10.1159/000132708
[Indexed for MEDLINE]
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