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Pathol Biol (Paris). 2009 Sep;57(6):477-82. doi: 10.1016/j.patbio.2008.05.006. Epub 2008 Jun 30.

A notable accessory screening program for detection of cervical intraepithelial neoplasia.

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1
School of Nursing College, Chung Shan Medical University, Taichung, Taiwan.

Abstract

OBJECTIVE:

Papanicolaou (Pap) smear test is implemented to detect cervical intraepithelial neoplasia (CIN) in Taiwan. However, the utility of that has limitations. High-risk human papillomavirus (HR-HPV) is an important risk factor in development of cervical cancer. In this study, we estimate the utility of HR-HPV testing in the screening of CIN.

METHODS:

Firstly, 726 subjects were recruited and willing to prove cervical exfoliated epithelial cells for Pap smear screening and HR-HPV DNA testing. Subsequently, 205 of the eligible subjects with greater than or equal to CIN1 of Pap smear results were asked to perform histologic diagnosis that served as a gold standard for the estimation of the effects of both Pap smear and HR-HPV testing.

RESULTS:

The histology is significantly associated with HR-HPV infection, as well as significantly highly correlated with the individuals who have both Pap smear greater than or equal to CIN1 and positive HR-HPV infection but not significantly correlated with the individuals who only have Pap smear greater than or equal to CIN1 but without HR-HPV infection.

CONCLUSIONS:

Combinative surveillance of HR-HPV infection and Pap smear is a useful tool to detect and monitor precancerous lesions in the screening program. HR-HPV testing is a notable accessory screening program for detection of CIN in Taiwanese women.

PMID:
18586410
DOI:
10.1016/j.patbio.2008.05.006
[Indexed for MEDLINE]

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