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Trends Genet. 2008 Aug;24(8):375-8. doi: 10.1016/j.tig.2008.05.006. Epub 2008 Jun 27.

Rapidly regulated genes are intron poor.

Author information

1
Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK. dcj@sanger.ac.uk

Erratum in

  • Trends Genet. 2008 Oct;24(10):488.

Abstract

We show that genes with rapidly changing expression levels in response to stress contain significantly lower intron densities in yeasts, thale cress and mice. Therefore, we propose that introns can delay regulatory responses and are selected against in genes whose transcripts require rapid adjustment for survival of environmental challenges. These findings could provide an explanation for the apparent extensive intron loss during the evolution of some eukaryotic lineages.

PMID:
18586348
DOI:
10.1016/j.tig.2008.05.006
[Indexed for MEDLINE]

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