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Biochim Biophys Acta. 2008 Sep;1781(9):563-70. doi: 10.1016/j.bbalip.2008.05.008. Epub 2008 Jun 10.

Roles of lysophosphatidic acid in cardiovascular physiology and disease.

Author information

1
Department of Veterans Affairs Medical Center, Lexington, Kentucky 40511, USA. susansmyth@uky.edu

Abstract

The bioactive lipid mediator lysophosphatidic acid (LPA) exerts a range of effects on the cardiovasculature that suggest a role in a variety of critical cardiovascular functions and clinically important cardiovascular diseases. LPA is an activator of platelets from a majority of human donors identifying a possible role as a regulator of acute thrombosis and platelet function in atherogenesis and vascular injury responses. Of particular interest in this context, LPA is an effective phenotypic modulator of vascular smooth muscle cells promoting the de-differentiation, proliferation and migration of these cells that are required for the development of intimal hyperplasia. Exogenous administration of LPA results in acute and systemic changes in blood pressure in different animal species, suggesting a role for LPA in both normal blood pressure regulation and hypertension. Advances in our understanding of the molecular machinery responsible for the synthesis, actions and inactivation of LPA now promise to provide the tools required to define the role of LPA in cardiovascular physiology and disease. In this review we discuss aspects of LPA signaling in the cardiovasculature focusing on recent advances and attempting to highlight presently unresolved issues and promising avenues for further investigation.

PMID:
18586114
PMCID:
PMC2572771
DOI:
10.1016/j.bbalip.2008.05.008
[Indexed for MEDLINE]
Free PMC Article

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