Send to

Choose Destination
See comment in PubMed Commons below
Exp Gerontol. 2008 Aug;43(8):718-28. doi: 10.1016/j.exger.2008.05.016. Epub 2008 Jun 11.

Innate immunity and aging.

Author information

  • 1The Burn and Shock Trauma Institute, Loyola University Medical Center, Maywood, IL 60153, USA.


Advanced age is associated with defects in all of the cells of the innate immune system, including numbers, function, and early stages of activation. This review, presents the current state of the field on the impact of age on the innate immune system. The analysis of the literature suggests that a dysfunctional innate immune system is a contributing factor to aberrant outcomes after injury or infection and to the development of many of the diseases observed in the elderly. Gaining an understanding of the nature of the defects in innate immune cells may allow the development of therapeutic strategies aimed to restore innate immune function in aged individuals.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk