Format

Send to

Choose Destination
See comment in PubMed Commons below
Biochimie. 2009 Jan;91(1):52-7. doi: 10.1016/j.biochi.2008.05.021. Epub 2008 Jun 10.

Twenty-five years of research on bovine lactoferrin applications.

Author information

1
Dairy Techno Inc., 2-3-9 Shiba, Minato-ku, Tokyo 105-0014, Japan.

Abstract

Lactoferrin (LF) was identified as a milk protein in 1960. Large-scale manufacturing of bovine LF (bLF) was established more than 20 years ago. Using this commercially available material, research for bLF applications has advanced from basic studies to clinical studies, and bLF has been applied to commercial food products for the last 25 years. During this period, it was found that LF is digested by gastric pepsin to generate a multi-potent peptide, lactoferricin. It was also demonstrated that oral administration of bLF augments host protection against infections via antimicrobial action and immunomodulation of the host. In addition, researchers have demonstrated that oral administration of bLF prevents cancer development. In this review, we look back on 25 years of bLF research and development.

PMID:
18585434
DOI:
10.1016/j.biochi.2008.05.021
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center