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Cell. 2008 Jun 27;133(7):1139-41. doi: 10.1016/j.cell.2008.06.011.

Hedgehog nanopackages ready for dispatch.

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1
MRC National Institute of Medical Research, Mill Hill, London, NW7 1AA, UK. jvincen@nimr.mrc.ac.uk

Abstract

Hedgehog proteins are intercellular long-range signaling molecules that spread within tissues and activate gene expression during development. Vyas et al. (2008) propose that Hedgehog forms nanometer-sized oligomers that localize in proteoglycan-rich clusters at the surface of cells expressing Hedgehog. This nanoscale organization and enrichment in clusters ensures that Hedgehog is able to spread and activate signaling over many cell diameters.

PMID:
18585347
DOI:
10.1016/j.cell.2008.06.011
[Indexed for MEDLINE]
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