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Cell. 2008 Jun 27;133(7):1135-7. doi: 10.1016/j.cell.2008.06.003.

Forging new ties between E. coli genes.

Author information

1
Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA. grey@bioeng.ucsd.edu

Abstract

A recent study in Nature (Isalan et al., 2008) has examined the effects of systematically adding new transcriptional interactions in the bacterium Escherichia coli. Surprisingly, the majority of the engineered connections have no effect on growth, and in some cases the new connections enhance fitness. These findings reveal insights into the robustness and evolvability of gene networks.

PMID:
18585345
PMCID:
PMC2806683
DOI:
10.1016/j.cell.2008.06.003
[Indexed for MEDLINE]
Free PMC Article

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