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Trends Cell Biol. 2008 Aug;18(8):357-9. doi: 10.1016/j.tcb.2008.05.005. Epub 2008 Jun 26.

Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition.

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1
Departamento de Bioquímica UAM, Instituto de Investigaciones Biomédicas Alberto Sols CSIC-UAM Arturo Duperier 4, 28029 Madrid, Spain. acano@iib.uam.es

Abstract

Noncoding RNAs are emerging as central players in gene expression regulation through the targeting of a plethora of mRNAs. Several recent papers report on the regulation of the epithelial phenotype by the miR-200 (200 family of miRNAs) family and a natural antisense transcript, both acting on the E-cadherin repressors zinc-finger E-box-binding homeobox factors ZEB1 and ZEB2. These findings open new avenues for understanding the modulation of the epithelial-to-mesenchymal transition in physiological and pathological situations.

PMID:
18585040
DOI:
10.1016/j.tcb.2008.05.005
[Indexed for MEDLINE]
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