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Ophthalmology. 2008 Nov;115(11):1938-43. doi: 10.1016/j.ophtha.2008.05.016. Epub 2008 Jun 26.

Triamcinolone acetonide in silicone-filled eyes as adjunctive treatment for proliferative vitreoretinopathy: a randomized clinical trial.

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1
Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University, M.C., Tehran, Iran.

Abstract

OBJECTIVE:

To evaluate the effect of adjunctive intraocular triamcinolone acetonide (TA) in silicone-filled eyes on outcomes of vitreoretinal surgery for proliferative vitreoretinopathy (PVR).

DESIGN:

Prospective, randomized, controlled clinical trial.

PARTICIPANTS:

Seventy-five eyes with rhegmatogenous retinal detachment and PVR grade C (posterior, anterior, or both) undergoing vitrectomy combined with silicone oil tamponade were included. Of these, 38 eyes were assigned randomly to the adjunctive treatment, whereas 37 eyes served as controls.

INTERVENTION:

All eyes underwent pars plana vitrectomy, membrane peeling, and silicone oil exchange, with or without relaxing retinotomy or retinectomy. In the treatment group, 4 mg TA was injected into the silicone-filled vitreous cavity at the end of the procedure. Silicone oil was removed 3 months after surgery in eyes with attached retinas.

MAIN OUTCOME MEASURES:

The primary outcome measure was retinal reattachment rate at 6 months. Secondary outcome measures included visual acuity, rate of recurrent PVR, reoperation rate, and rise of intraocular pressure.

RESULTS:

Retinal reattachment without any reoperation was achieved in 32 eyes (84.2%) and 29 eyes (78.4%) in the adjunctive treatment and control groups, respectively, at 6 months (P = 0.5). No statistically significant difference was observed between the 2 groups in terms of any of the secondary outcome measures (P>0.05).

CONCLUSIONS:

The outcomes of vitreoretinal surgery for established PVR are not improved significantly by adjunctive TA injection in silicone-filled eyes.

PMID:
18584876
DOI:
10.1016/j.ophtha.2008.05.016
[Indexed for MEDLINE]
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