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Cancer Invest. 2008 Jul;26(6):615-23. doi: 10.1080/07357900701837051.

Identification of galectin-3 and mucin-type O-glycans in breast cancer and its metastasis to brain.

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Laboratorio Experimental de Enfermedades Neurodegenerativas, Instituto Nacional de Neurologia y Neurocirugia, Del Tlalpan, Mexico.


Galectin-3 has been implicated in tumor progression. We demonstrated immunohistochemically that galectin-3 was negative in normal breast tissue, but it was highly increased in breast cancer and in metastatic tissues to brain. Similarly, histochemistry with mucin-specific lectins showed increased recognition in breast tumor and metastasis with Machaerocereus eruca agglutinin (Fualpha 1,2 (GalNAcalpha 1,3) Galss1,4 in complex mucin) but not for Amaranthus leucocarpus (Galss1,3-GalNAc-alpha 1,0-Ser/Thr) and Arachis hypogaea lectins (Galss1,3GalNAc/Galss1,4GlcNAc). Mucin-type glycans and galectin-3 colocalized in breast cancer and metastasis, but not in normal tissue, suggesting upregulated biosynthesis of complex O-glycosidically linked glycans and galectin-3 favor breast cancer progression and brain metastasis.

[Indexed for MEDLINE]

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