Format

Send to

Choose Destination
See comment in PubMed Commons below
Cancer Invest. 2008 Jul;26(6):615-23. doi: 10.1080/07357900701837051.

Identification of galectin-3 and mucin-type O-glycans in breast cancer and its metastasis to brain.

Author information

1
Laboratorio Experimental de Enfermedades Neurodegenerativas, Instituto Nacional de Neurologia y Neurocirugia, Del Tlalpan, Mexico.

Abstract

Galectin-3 has been implicated in tumor progression. We demonstrated immunohistochemically that galectin-3 was negative in normal breast tissue, but it was highly increased in breast cancer and in metastatic tissues to brain. Similarly, histochemistry with mucin-specific lectins showed increased recognition in breast tumor and metastasis with Machaerocereus eruca agglutinin (Fualpha 1,2 (GalNAcalpha 1,3) Galss1,4 in complex mucin) but not for Amaranthus leucocarpus (Galss1,3-GalNAc-alpha 1,0-Ser/Thr) and Arachis hypogaea lectins (Galss1,3GalNAc/Galss1,4GlcNAc). Mucin-type glycans and galectin-3 colocalized in breast cancer and metastasis, but not in normal tissue, suggesting upregulated biosynthesis of complex O-glycosidically linked glycans and galectin-3 favor breast cancer progression and brain metastasis.

PMID:
18584353
DOI:
10.1080/07357900701837051
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis
    Loading ...
    Support Center