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Cancer Invest. 2008 Jul;26(6):562-8. doi: 10.1080/07357900701816477.

Interferon-alpha inhibits proliferation and induces apoptosis of merkel cell carcinoma in vitro.

Author information

1
Department of Dermatology, Faculty of Medicine, University of Crete, Heraklion, Greece. krasagak@med.uoc.gr

Abstract

Merkel cell carcinoma is a tumor with aggressive biological behavior and limited response to chemotherapy. The present study investigated the effect of interferon (IFN)-alpha on growth and apoptosis of Merkel carcinoma cells in vitro. Proliferation of MCC-1 cell line was reduced dose-dependently by IFN-alpha and diminished when higher IFN-alpha concentrations were used. Additionally, IFN-alpha potently decreased DNA-synthesis and Ki67/MIB-1 proliferation index of MCC-1 cultures. Furthermore, IFN-alpha induced dose-dependently apoptosis of MCC-1 cells as shown by caspase-3 activation, and detection of apoptotic DNA strand breaks and fragmented nuclei. These findings suggest that IFN-alpha may have antitumor activity against Merkel cell carcinoma.

PMID:
18584346
DOI:
10.1080/07357900701816477
[Indexed for MEDLINE]

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