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Ir J Med Sci. 2008 Sep;177(3):225-31. doi: 10.1007/s11845-008-0167-6. Epub 2008 Jun 27.

Invasive pneumococcal disease in children in Ireland--the anticipated benefit of conjugate pneumococcal vaccination.

Author information

1
Department of Paediatric Infectious Diseases, Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland. john.fitzsimons@royalfree.nhs.uk

Abstract

BACKGROUND:

Streptococcus pneumoniae is an important cause of childhood illness. Recently a safe and effective 7-valent conjugate pneumococcal vaccine for children has been licensed in the EU.

AIMS:

To calculate the incidence of invasive pneumococcal disease (IPD) in children in Ireland, to estimate the burden of disease and to anticipate the protective effect of the conjugate vaccine.

METHODS:

Retrospective review of data from children with IPD.

RESULTS:

Ninety-six cases of IPD in 95 children including two related deaths were identified. All childhood IPD incidence was estimated at 10.6/100,000. We anticipate that the 7-valent conjugate vaccine could prevent up to 90% of sepsis and up to 82.5% of meningitis cases.

CONCLUSIONS:

IPD is an important cause of mortality and morbidity in children in Ireland. Routine use of conjugate pneumococcal vaccine would have a significant impact on pneumococcal disease, especially in vaccinated children but also in unvaccinated children and older adults.

PMID:
18584271
DOI:
10.1007/s11845-008-0167-6
[Indexed for MEDLINE]
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