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Ann Clin Biochem. 2008 Jul;45(Pt 4):409-12. doi: 10.1258/acb.2008.007251.

Protein S-100 is present in extracerebral fluids before and after cardiac surgery in children.

Author information

1
Department of Congenital Heart Disease, Germany. nagdyman@dhzb.de

Abstract

BACKGROUND:

Protein S-100 is found in extracerebral sources. The aim of our study was to examine the content of protein S-100 in native pericardial fluid as well as in postoperative extracerebral fluids after cardiac surgery in children.

METHODS:

We conducted a prospective study in 90 children measuring protein S-100 concentration in pericardial fluid directly after opening the pericardial sac before starting with cardiac surgery. Postoperatively, we examined pleural, peritoneal and pericardial fluid.

RESULTS:

Pericardial fluid sampled directly after opening the pericardial sac has a protein S-100 content of 3.2 (1.3-5.4) microg/L. Postoperatively, protein S-100 content was 0.89 (0.56-2.6) microg/L in pleural effusion, 0.14 (0.1-1.1) microg/L in peritoneal fluid and 2.75 (2.2-24.4) microg/L in pericardial fluid. The protein S-100 concentration in pericardial fluid before and after cardiac operation did not differ significantly. Pericardial protein S-100 concentrations were significantly higher than pleural and peritoneal protein S-100 concentrations.

CONCLUSIONS:

Protein S-100 is present in extracerebral fluids before and after cardiac surgery in children. The time point of fluid withdrawal after the operation did not influence the protein S-100 concentration.

PMID:
18583627
DOI:
10.1258/acb.2008.007251
[Indexed for MEDLINE]

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