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J Clin Endocrinol Metab. 2008 Oct;93(10):3810-6. doi: 10.1210/jc.2008-0817. Epub 2008 Jun 26.

Quality of reporting of randomized controlled trials in general endocrinology literature.

Author information

1
Father Sean O'Sullivan Research Centre, St. Joseph's Healthcare, Hamilton, Ontario, L8N 4A6 Canada.

Abstract

CONTEXT:

The reporting quality of randomized controlled trials (RCTs) is poor in general medicine and several areas of specialization but unknown in endocrinology.

OBJECTIVE:

Our aim was to assess the reporting quality of RCTs in general endocrinology. A secondary objective was to identify predictors for better reporting quality.

DESIGN AND SETTING:

We systematically reviewed RCTs published in three general endocrinology journals between January 2005 and December 2006.

PARTICIPANTS:

We included parallel-design RCTs that addressed a question of treatment or prevention. Article selection and data abstraction were conducted by two reviewers independently, and disagreements were resolved by consensus.

MAIN OUTCOMES:

There were two main outcomes: 1) a 15-point overall reporting quality score (OQS) based on the Consolidated Standards for Reporting Trials (CONSORT); and 2) a 3-point key score, based on allocation concealment, blinding, and use of intention-to-treat analysis.

RESULTS:

Eighty nine RCTs were included. The median OQS was 10 (interquartile range = 2). Allocation concealment, blinding, and analysis by intention to treat were reported in 10, 20, and 16 of the 89 RCTs, respectively. A multivariable regression analysis showed that complete industrial funding [incidence rate ratio (IRR) = 1.014; 95% confidence interval (CI), 1.010-1.018], journal of publication (IRR = 1.068; 95% CI, 1.007-1.132), and sample size (IRR = 1.048; 95% CI, 1.026-1.070) were significantly associated with a slightly better OQS.

CONCLUSIONS:

The quality of RCT reporting in general endocrine literature is suboptimal. We discuss our results, highlight the areas where improvements are needed, and provide some recommendations.

PMID:
18583463
DOI:
10.1210/jc.2008-0817
[Indexed for MEDLINE]

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