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Colloids Surf B Biointerfaces. 2008 Oct 1;66(1):26-33. doi: 10.1016/j.colsurfb.2008.05.007. Epub 2008 May 20.

The synthesis of biodegradable graft copolymer cellulose-graft-poly(L-lactide) and the study of its controlled drug release.

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1
Department of Polymer Science, Key Laboratory of Biomedical Polymers, Wuhan University, Ministry of Education, Wuhan 430072, People's Republic of China.

Abstract

According to the concept of green chemistry and sustainable development, a new biodegradable copolymer comprised of hydrophobic poly(l-lactide) (PLLA) segments and hydrophilic cellulose segment (cellulose-g-PLLA) was designed and synthesized. The structure of the copolymer was characterized by (1)H NMR, FT-IR, (13)C NMR, DSC and WAXD. The cytotoxicity study shows that cellulose-g-PLLA exhibits good biocompatibility. The copolymer can self-assemble into micelles in water with the hydrophobic PLLA segments at the cores of micelles and the hydrophilic cellulose segments as the outer shells. Transmission electron microscopy (TEM) shows that the micelles exhibit nanospheric morphology within a size range of 30-80nm. The drug loaded micelles formed by the copolymer in aqueous media show sustained drug release which indicates their potential applicability in drug carrier.

PMID:
18583109
DOI:
10.1016/j.colsurfb.2008.05.007
[Indexed for MEDLINE]
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