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Diagn Microbiol Infect Dis. 2008 Sep;62(1):99-101. doi: 10.1016/j.diagmicrobio.2008.04.008. Epub 2008 Jun 25.

Pharmacokinetics-pharmacodynamics of quinolones against Streptococcus pneumoniae in patients with community-acquired pneumonia.

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Institute for Clinical Pharmacodynamics, Ordway Research Institute, Albany, NY 12206-1072, USA.


Exposure-response analyses were performed using data from 89 patients (10 clinical trials) with Streptococcus pneumoniae community-acquired pneumonia who received quinolones. Relationships between the free-drug AUC/MIC ratio and clinical and microbiologic response were identified. Such data may be useful to establish prior expectations for the no-treatment effect when conducting noninferiority clinical trials.

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