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Semin Hematol. 2008 Jul;45(3):135-40. doi: 10.1053/j.seminhematol.2008.04.003.

A dirty dozen: twelve p-value misconceptions.

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1
Departments of Oncology, Epidemiology, and Biostatistics, Johns Hopkins Schools of Medicine and Public Health, Baltimore, MD, USA. Sgoodman@jhmi.edu

Erratum in

  • Semin Hematol. 2011 Oct;48(4):302.

Abstract

The P value is a measure of statistical evidence that appears in virtually all medical research papers. Its interpretation is made extraordinarily difficult because it is not part of any formal system of statistical inference. As a result, the P value's inferential meaning is widely and often wildly misconstrued, a fact that has been pointed out in innumerable papers and books appearing since at least the 1940s. This commentary reviews a dozen of these common misinterpretations and explains why each is wrong. It also reviews the possible consequences of these improper understandings or representations of its meaning. Finally, it contrasts the P value with its Bayesian counterpart, the Bayes' factor, which has virtually all of the desirable properties of an evidential measure that the P value lacks, most notably interpretability. The most serious consequence of this array of P-value misconceptions is the false belief that the probability of a conclusion being in error can be calculated from the data in a single experiment without reference to external evidence or the plausibility of the underlying mechanism.

[Indexed for MEDLINE]

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