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Org Lett. 2008 Aug 7;10(15):3227-30. doi: 10.1021/ol801112j. Epub 2008 Jun 27.

Ultrafast reversible photo-cross-linking reaction: toward in situ DNA manipulation.

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1
School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan.

Abstract

We describe a novel ultrafast reversible DNA interstrand photo-cross-linking reaction via 3-cyanovinylcarbazole nucleoside ( (CNV)K). Oligodeoxynucleotide (ODN) containing (CNV)K can be photo-cross-linked by irradiation at 366 nm for 1 s, and the photo-cross-linked ODN can be split by irradiation at 312 nm for 60 s.

PMID:
18582065
DOI:
10.1021/ol801112j
[Indexed for MEDLINE]
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