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Trends Biochem Sci. 1991 Feb;16(2):58-62.

News from the nucleolus: rRNA gene expression.

Author information

1
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2185.

Abstract

Although the typical, actively growing eukaryotic cell contains over 10,000 different transcripts, half of its RNA synthetic capacity is devoted to the production of a single kind of RNA. This is the pre-ribosomal RNA, which is synthesized in a special compartment of the nucleus, the nucleolus, and is the exclusive product of transcription by RNA polymerase I. In vivo and in vitro approaches have revealed the major features of rRNA gene transcription and of the subsequent processing of the primary transcript.

PMID:
1858134
DOI:
10.1016/0968-0004(91)90025-q
[Indexed for MEDLINE]

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