Send to

Choose Destination
See comment in PubMed Commons below
Neurosurgery. 2008 May;62(5):1095-102; discussion 1102-3. doi: 10.1227/01.neu.0000325871.60129.23.

A multicenter study of factors influencing cerebrospinal fluid shunt survival in infants and children.

Author information

  • 1Department of Pediatrics and The Center for Clinical Epidemiology and Biostatistics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.



To identify factors influencing the duration of cerebrospinal fluid shunt survival after initial placement and after subsequent revisions.


We conducted a retrospective cohort study using the Pediatric Health Information System database, which contains resource use data from 37 tertiary care children's hospitals. Children younger than 18 years who underwent initial cerebrospinal fluid placement between January 1, 2000, and December 31, 2005, were eligible.


During the study period, 20.2, 7.5, and 6.9% of 7399 patients required one, two, or three or more shunt revisions, respectively. Shunt survival rates were lower with each subsequent shunt revision. In multivariable Cox proportional hazards analysis, children undergoing shunt placement in the Northeast census region had a longer duration of shunt survival between initial placement and both the first (adjusted hazard ratio, 0.74; 95% confidence interval, 0.55-0.99) and second (adjusted hazard ratio, 0.66; 95% confidence interval, 0.51-0.86) revisions. Young age and a principal diagnosis of obstructive hydrocephalus were also associated with a higher risk of failure after initial placement; age-related variation in shunt survival persisted after the first but not the second revision. Among patients with multiple shunt revisions, those with early revision (i.e., revision <60 d after placement) had a shorter shunt survival time after subsequent revisions (adjusted hazard ratio for second revision, 1.30; 95% confidence interval, 1.11-1.52).


Regional variation in the risk of ventricular shunt revision exists, and young infants are at the highest risk for shunt failure. Risk factors for the duration of shunt survival differ between the initial and subsequent revisions.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk