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AIDS. 2008 Jul 11;22(11):1371-4. doi: 10.1097/QAD.0b013e3283018504.

Impact of antiretroviral therapy on chemokine (C-C motif) receptor 5 expression in HIV patients followed for over 2 years.

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1
Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain.

Abstract

Suppression of HIV replication using highly active antiretroviral therapy (HAART) might influence chemokine (C-C motif) receptor 5 expression on infected cells and therefore modulate the activity of chemokine (C-C motif) receptor 5 antagonists. Chemokine (C-C motif) receptor 5 expression was examined longitudinally in 26 HIV-infected adults who initiated HAART. Long-term suppression of plasma HIV-RNA did not significantly influence chemokine (C-C motif) receptor 5 expression on T lymphocytes. Therefore, the activity of chemokine (C-C motif) receptor 5 antagonists should not differ before and following HIV suppression on HAART.

PMID:
18580618
DOI:
10.1097/QAD.0b013e3283018504
[Indexed for MEDLINE]
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