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Ann Surg. 2008 Jul;248(1):1-7. doi: 10.1097/SLA.0b013e31816a9d65.

The long-term results of a randomized clinical trial of laparoscopy-assisted versus open surgery for colon cancer.

Author information

1
Department of Surgery, Centro de Investigaciones Biomédicas Esther Koplowitz, IMDiM, IDIBAPS, Hospital Clínic, University of Barcelona, Spain. alacy@clinic.ub.es

Abstract

OBJECTIVE:

The aim of this study was to compare the long-term outcome of laparoscopy-assisted colectomy (LAC) and open colectomy (OC) for nonmetastatic colon cancer.

METHODS:

From November 1993 to July 1998 all patients with adenocarcinoma of the colon were assessed for entry in this single center, clinically randomized trial. Adjuvant therapy and postoperative follow-up were similar in both groups. The primary endpoint was cancer-related survival and secondary endpoints were probability of overall survival and probability of being free of recurrence. Data were analyzed according the intention-to-treat principle.

RESULTS:

Two hundred and nineteen patients entered the study (111 LAC group and 108 OC group). The median follow-up was 95 months (range, 77-133). There was a tendency of higher cancer-related survival (P = 0.07, NS) and overall survival (P = 0.06, NS) for the LAC group. Probability of cancer-related survival was higher in the LAC group (P = 0.02) when compared with OC. The regression analysis showed that LAC was independently associated with a reduced risk of tumor relapse (hazard ratio 0.47, 95% CI 0.23-0.94), death from a cancer-related cause (0.44, 0.21-0.92) and death from any cause (0.59, 0.35-0.98).

CONCLUSIONS:

LAC is more effective than OC in the treatment of colon cancer.

PMID:
18580199
DOI:
10.1097/SLA.0b013e31816a9d65
[Indexed for MEDLINE]

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