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J Virol. 2008 Sep;82(17):8896-9. doi: 10.1128/JVI.00406-08. Epub 2008 Jun 25.

Human embryonic stem cell-derived oligodendrocyte progenitor cells express the serotonin receptor and are susceptible to JC virus infection.

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1
Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA.

Abstract

We studied the susceptibility of human embryonic stem cell-derived oligodendrocyte progenitor cells to infection with JC virus, the causative agent of progressive multifocal leukoencephalopathy (PML). A human embryonic stem cell line, H7, was used to derive an enriched population of cells expressing the oligodendrocyte progenitor cell-specific marker NG2. These cells expressed the 5HT2a receptor (5HT2aR) for JC virus and were highly susceptible to infection. Infection was reduced by treatment with anti-5HT2aR antibodies and by the 5HT2aR antagonists ritanserin and ketanserin. This is the first demonstration that human embryonic stem cell-derived oligodendrocyte progenitor cells are susceptible to JC virus infection and indicates that cells poised to replenish mature oligodendrocytes in PML lesions may also be a target of viral infection.

PMID:
18579595
PMCID:
PMC2519689
DOI:
10.1128/JVI.00406-08
[Indexed for MEDLINE]
Free PMC Article
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