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Biochem Biophys Res Commun. 2008 Aug 29;373(3):429-34. doi: 10.1016/j.bbrc.2008.06.046. Epub 2008 Jun 23.

6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes.

Author information

1
College of Bioscience and Biotechnology, Chubu University, Kasugai, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan.

Abstract

In this study, we demonstrated that the two ginger-derived components have a potent and unique pharmacological function in 3T3-L1 adipocytes via different mechanisms. Both pretreatment of 6-shogaol (6S) and 6-gingerol (6G) significantly inhibited the tumor necrosis factor-alpha (TNF-alpha) mediated downregulation of the adiponectin expression in 3T3-L1 adipocytes. Our study demonstrate that (1) 6S functions as a PPARgamma agonist with its inhibitory mechanism due to the PPARgamma transactivation, and (2) 6G is not a PPARgamma agonist, but it is an effective inhibitor of TNF-alpha induced c-Jun-NH(2)-terminal kinase signaling activation and thus, its inhibitory mechanism is due to this inhibitory effect.

PMID:
18577375
DOI:
10.1016/j.bbrc.2008.06.046
[Indexed for MEDLINE]

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