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Pediatr Dermatol. 2008 May-Jun;25(3):403-4. doi: 10.1111/j.1525-1470.2008.00699.x.

The use of naltrexone in the management of severe generalized pruritus in biliary atresia: report of a case.

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Department of Dermatology, Loma Linda University Medical Center, Loma Linda, California, USA.


Generalized pruritus secondary to cholestasis is a difficult dermatologic condition to treat. We present a case of a 17-month-old child with congenital biliary atresia with generalized pruritus refractory to treatment with oral antihistamines, topical steroids, cholestyramine, and rifampin but improved remarkably with the addition of naltrexone. Naltrexone is a well-tolerated medication with little adverse effects. We believe that naltrexone may be an effective adjuvant treatment in the management of cholestatic pruritus in the pediatric population.

[Indexed for MEDLINE]

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