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Nat Rev Cancer. 2008 Jul;8(7):512-22. doi: 10.1038/nrc2440.

Living on a break: cellular senescence as a DNA-damage response.

Author information

1
IFOM Foundation, FIRC Institute of Molecular Oncology Foundation, via Adamello 16, 20139 Milan, Italy. fabrizio.dadda@ifom-ieo-campus.it

Abstract

Cellular senescence is associated with ageing and cancer in vivo and has a proven tumour-suppressive function. Common to both ageing and cancer is the generation of DNA damage and the engagement of the DNA-damage response pathways. In this Review, the diverse mechanisms that lead to DNA-damage generation and the activation of DNA-damage-response signalling pathways are discussed, together with the evidence for their contribution to the establishment and maintenance of cellular senescence in the context of organismal ageing and cancer development.

PMID:
18574463
DOI:
10.1038/nrc2440
[Indexed for MEDLINE]
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