Send to

Choose Destination
Annu Rev Biophys. 2008;37:175-95. doi: 10.1146/annurev.biophys.37.032807.125859.

PIP2 is a necessary cofactor for ion channel function: how and why?

Author information

Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98195, USA.


Phosphatidylinositol 4,5-bisphosphate (PIP2) is a minority phospholipid of the inner leaflet of plasma membranes. Many plasma membrane ion channels and ion transporters require PIP2 to function and can be turned off by signaling pathways that deplete PIP2. This review discusses the dependence of ion channels on phosphoinositides and considers possible mechanisms by which PIP2 and analogues regulate ion channel activity.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center