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J Ethnopharmacol. 2008 Aug 13;118(3):435-9. doi: 10.1016/j.jep.2008.05.008. Epub 2008 May 15.

Identification of pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits.

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1
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.

Abstract

AIM OF THE STUDY:

To identify pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits.

MATERIAL AND METHODS:

Streptozotocin-induced diabetic rats and hyperglycemic, hyperlipidemic and hyperinsulinemic db/db mice were used to investigate the antihyperglycemic activity of pongamol and karangin isolated from the fruits of Pongamia pinnata.

RESULTS:

In streptozotocin-induced diabetic rats, single dose treatment of pongamol and karanjin lowered the blood glucose level by 12.8% (p<0.05) and 11.7% (p<0.05) at 50mg /kg dose and 22.0% (p<0.01) and 20.7% (p<0.01) at 100mg/kg dose, respectively after 6h post-oral administration. The compounds also significantly lowered blood glucose level in db/db mice with percent activity of 35.7 (p<0.01) and 30.6 (p<0.01), respectively at 100mg/kg dose after consecutive treatment for 10 days. The compounds were observed to exert a significant inhibitory effect on enzyme protein tyrosine phosphatase-1B (EC 3.1.3.48).

CONCLUSION:

The results showed that pongamol and karangin isolated from the fruits of Pongamia pinnata possesses significant antihyperglycemic activity in Streptozotocin-induced diabetic rats and type 2 diabetic db/db mice and protein tyrosine phosphatase-1B may be the possible target for their activity.

PMID:
18572336
DOI:
10.1016/j.jep.2008.05.008
[Indexed for MEDLINE]

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