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Reprod Toxicol. 2008 Sep;26(1):19-23. doi: 10.1016/j.reprotox.2008.05.053. Epub 2008 May 13.

The safety of cetirizine during pregnancy. A prospective observational cohort study.

Author information

1
Pharmakovigilanz- und Beratungszentrum Embryonaltoxikologie Berlin, Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Spandauer Damm 130, Haus 10, 14050 Berlin, Germany. weber@embryotox.de

Abstract

OBJECTIVE:

To assess the safety of cetirizine during pregnancy.

STUDY DESIGN:

A prospective observational cohort study with data of the Berlin teratology information center from 1992 until 2006. Pregnancy outcome was compared between a cohort of pregnant women exposed to cetirizine during the first trimester (n=196) and a control group not exposed to potential teratogens (n=1686).

RESULTS:

Major birth defects were not more common in the study group than in the control group (OR 1.07; CI 0.21-3.59). We also compared the crude rate of spontaneous abortions (OR 0.97; CI 0.54-1.65), of preterm deliveries (OR 0.76; CI 0.35-1.5), and the birth weight of term newborns (p=0.13).

CONCLUSIONS:

This prospective observational study on cetirizine in pregnancy suggests that the use of cetirizine is relatively safe during the first trimester.

PMID:
18571373
DOI:
10.1016/j.reprotox.2008.05.053
[Indexed for MEDLINE]

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