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Behav Brain Res. 2008 Dec 16;195(1):198-213. doi: 10.1016/j.bbr.2008.03.020. Epub 2008 Mar 25.

Molecular biology of 5-HT receptors.

Author information

1
Nervous System Research, WSJ.386.745, Novartis Institute for Biomedical Research, CH-4002 Basel, Switzerland.

Abstract

Serotonin (5-hydroxytryptamine; 5-HT) is a monoamine neurotransmitter whose effects are mediated by at least 13 distinct G protein-coupled receptors (GPCRs) of the type A family which includes the monoamine receptors and a combination of ligand-gated ion channels (5-HT3) of the Cys loop family which constitutes heteropentamers. 5-HT receptors are currently divided into seven classes (5-HT1 to 5-HT7), based on structural, transductional and operational features. While this degree of physical diversity clearly underscores the physiological importance of serotonin, evidence for an even greater degree of operational diversity is supported by the existence of a great number of splice and editing variants for several 5-HT receptors, their possible modulation by accessory proteins and chaperones, as well as their potential to form homo or heteromers both at the GPCR and at the ligand-gated channel level.

PMID:
18571247
DOI:
10.1016/j.bbr.2008.03.020
[Indexed for MEDLINE]

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