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Mol Cell. 2008 Jun 20;30(6):657-66. doi: 10.1016/j.molcel.2008.04.013.

"Nought may endure but mutability": spliceosome dynamics and the regulation of splicing.

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1
The Rockefeller University, New York, NY 10065, USA.

Abstract

The spliceosome is both compositionally and conformationally dynamic. Each transition along the splicing pathway presents an opportunity for progression, pausing, or discard, allowing splice site choice to be regulated throughout both the assembly and catalytic phases of the reaction.

PMID:
18570869
PMCID:
PMC2610350
DOI:
10.1016/j.molcel.2008.04.013
[Indexed for MEDLINE]
Free PMC Article
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