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Genome Biol. 2008;9(6):R100. doi: 10.1186/gb-2008-9-6-r100. Epub 2008 Jun 20.

Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype.

Author information

1
Cogenics, Division of Clinical Data, Inc, Morrisville, NC 27560, USA. elobenhofer@cogenics.com

Abstract

This report details the standardized experimental design and the different data streams that were collected (histopathology, clinical chemistry, hematology and gene expression from the target tissue (liver) and a bio-available tissue (blood)) after treatment with eight known hepatotoxicants (at multiple time points and doses with multiple biological replicates). The results of the study demonstrate the classification of histopathological differences, likely reflecting differences in mechanisms of cell-specific toxicity, using either liver tissue or blood transcriptomic data.

PMID:
18570634
PMCID:
PMC2481421
DOI:
10.1186/gb-2008-9-6-r100
[Indexed for MEDLINE]
Free PMC Article

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