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J Enzyme Inhib Med Chem. 2008 Jun;23(3):313-6. doi: 10.1080/14756360701536455 .

Butyrylcholinesterase, lipoxygenase inhibiting and antifungal alkaloids from Isatis tinctoria.

Author information

1
Medicinal Botanic Centre, PCSIR Laboratories Complex, Peshawar, N.W.F.P, Pakistan. drijaz_chem@yahoo.com

Abstract

Phytochemical investigations on the alkaloidal fraction of the whole plant of the Isatis tinctoria led to the isolation of the alkaloids 1-6. Compounds 3, 2 were found to be potent butyrylcholinesterase and lipoxygenase enzymes inhibitors in a concentration-dependent manner with the IC(50) values 16.3 +/- 0.06 and 19.7 +/- 0.03 microM against BChE and 30.6 +/- 0.02 and 33.7 +/- 0.05 microM against LOX, respectively. The compounds (1-6) showed significant antifungal activity against Trichophyton schoen leinii, Aspergillus niger, Candida albicans, Trichophyton simii, and Macrophomina phaseolina.

PMID:
18569333
DOI:
10.1080/14756360701536455
[Indexed for MEDLINE]

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