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Chem Soc Rev. 2008 Jul;37(7):1432-47. doi: 10.1039/b703021p. Epub 2008 Jun 2.

Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria.

Author information

1
Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706-1322, USA.

Abstract

Bacteria are capable of "communicating" their local population densities via a process termed quorum sensing (QS). Gram-negative bacteria use N-acylated l-homoserine lactones (AHLs), in conjunction with their cognate LuxR-type receptors, as their primary signalling circuit for QS. In this critical review, we examine AHL signalling in Gram-negative bacteria with a primary focus on the design of non-natural AHLs, their structure-activity relationships, and their application in chemical biological approaches to study QS (72 references).

PMID:
18568169
PMCID:
PMC2590586
DOI:
10.1039/b703021p
[Indexed for MEDLINE]
Free PMC Article

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