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Chem Soc Rev. 2008 Jul;37(7):1320-9. doi: 10.1039/b702780j. Epub 2008 May 21.

Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategy.

Author information

1
Tri-Institutional Training Program in Chemical Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 422, New York, NY 10065, USA.

Abstract

A variety of natural products modulate critical biological processes in the microorganisms that produce them. Thus, inhibition of the corresponding natural product biosynthesis pathways represents a promising avenue to develop novel antibiotics. In this tutorial review, we describe several recent examples of designed small molecule inhibitors of microbial natural product biosynthesis and their use in evaluating this emerging antibiotic strategy.

PMID:
18568158
PMCID:
PMC2587208
DOI:
10.1039/b702780j
[Indexed for MEDLINE]
Free PMC Article

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