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CNS Spectr. 2008 Jun;13(6):511-4.

Varenicline-induced mixed mood and psychotic episode in a patient with a past history of depression.

Author information

1
Department of Psychiatry, The Reading Hospital and Medical Center, West Reading, PA 19612, USA.

Abstract

Varenicline is a promising agent with demonstrated efficacy in the promotion of smoking cessation. However, from the time of initial trials, it has been associated with significant psychiatric adverse effects. We describe a case where mixed mood and psychotic disturbance developed in an individual with a history of depression and a family history of bipolar disorder. Based on this case, we hypothesize a possible mechanism of action for these adverse effects and preventive measures that could be undertaken in its effective use.

PMID:
18567975
DOI:
10.1017/s1092852900016746
[Indexed for MEDLINE]

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